The roast consisted of jokes toward Trump's hairstyle, his show The Apprentice, and his family.

During an interview on The View, Sheen's ex-wife, Denise Richards stated that she hadn't been invited to appear and, while she thought roasting her ex-husband could be humorous and that he would be able to take it, she feared it would have a negative impact on their daughters.

although Sheen appeared in a commercial for the roast, spoofing his film Apocalypse Now.

In the UK and Turkey, on the network which Two and a Half Men airs, The roast aired directly after Kutcher's first Two and a Half Men episode.

This was O'Neal's final television appearance before his death on November 29, 2011.

The tagline for this roast was "The Shat hits the fan." The Roast was nominated for a 2007 Primetime Emmy Award for Outstanding Variety Special.

The background music for the montage of Shatner was "Everything I Do, I Do with William Shatner" by the Star Trek-influenced rock band, Warp 11.Roasters: Jim Breuer, Mario Cantone, Lenny Clarke, Dane Cook, Nick Di Paolo, Doctor Dré, Adam Ferrara, Michael J. A special, pre-taped, guest appearance was made by Dr. Notable audience members: Adrian Zmed, David Carradine, Roger Corman, Brent Spiner, Jeri Ryan, René Auberjonois, Rosalind Chao, Mark Valley, Carrie Fisher, Scott Hamilton, Brad Paisley, Reno 911!Fox, Peter Gallagher, Don Gavin, Gina Gershon, Gilbert Gottfried as Denis' Irish Wolfhound, Ed Lover, Joe Mantegna, Conan O'Brien, Colin Quinn, Rene Russo, and Christopher Walken. Bush, Nick Di Paolo, Christian Finnegan, Greg Giraldo, Gilbert Gottfried as Jeff's cow, Heidi Klum, Lisa Lampanelli, Denis Leary, Jay Mohr, Patrice O'Neal, Colin Quinn, Anna Nicole Smith, and G. stars Cedric Yarbrough and Niecy Nash, and Brian Posehn.Pre-taped appearances were delivered by Sarah Silverman, Lewis Black, and Don Rickles.Notable audience members: Full House co-stars Lori Loughlin, Jodie Sweetin, and Dave Coulier along with Growing Pains star Alan Thicke, Rex Lee of Entourage and Quantum Leap & Star Trek: Enterprise star Scott Bakula and Alonzo Bodden.Several roasters paid respect to Greg Giraldo, a Comedy Central Roast regular, who died on September 29, 2010.